Carl F. Ware, PhD,  Director, Infectious and Inflammatory Diseases Center, Professor, Laboratory of Molecular Immunology, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA

Dr. Carl Ware is honored with the ICIS Honorary Lifetime Membership award as a tribute to his seminal and original contributions to our understanding of the role of cytokines in immunobiology and active engagement in cytokine research.

Dr. Ware’s career studying cytokines began in the early 1970’s at a time when the techniques we now take for granted were just being developed, and before the advent of molecular biology through his recent research directed at identifying translational opportunities in infectious, inflammatory diseases, and cancer. He identified the LIGHT-HEVEM pathway as the mechanism underlying an effective vaccine for Herpes Simplex Virus-1/2. Recently he showed that LIGHT levels are increased in COVID-19 patients progressing to pneumonia (Perlin, Safir-Levi et al, 2020) which launched a Phase 2 trial using the neutralized mAb to human LIGHT that he developed. Two other biologics created by the Ware group are for checkpoint inhibitor resistant cancers and follicular lymphoma.

Dr. Ware continues to apply his fundamental understanding of cytokine networks as a source of therapeutics for diseases without effective treatment. This was a time of ferment in the cytokine field as new supernatant biologic activities were being described at a rapid pace. This was a difficult time for many in the field, but Dr. Ware persisted, to the great benefit of the TNF field in particular, and the cytokine field in general. In later studies during a sabbatical at Biogen with Jeff Browning, he described LTβ. This molecule, when complexed with the original LTα, is a crucial contributor to the development of the lymphoid system. He went on to characterize additional members of the family including LIGHT and HVEM and solved problems that might have daunted others less tenacious with regard to the multiple interactions of the ligand receptor pairs in the expanded LT/TNF/LIGHT family. Dr. Ware has made fundamental discoveries concerning the role of the herpes virus entry mediator (HVEM), a member of the TNF receptor family. This has led to his elucidation of immune evasion mechanisms used by the various herpes viruses and provided important insight into the co-evolution of cytokine receptors and viruses. He is the holder of 6 patents and his discoveries have led to the development of novel therapeutics, namely, Baminercept, an LTbR-Fc fusion protein, and an anti-Light antibody. 

Dr. Ware continues to be extremely active- as witnessed by the success of his recent grant applications, including a $3 million grant from the National Institutes of Health (NIH) to study how SARS-CoV-19 weakens the immune system–and identify drugs to help infected individuals recover, as well as his steady publication record, including a paper on ILC3 regulation of cDCs to be published this month. His expertise is sought by many institutions, including the Manchot Graduate School at the University of Dusselforf where he serves on the Scientific Advisory Board.

Carl Ware has been an outstanding member of the scientific community in general and the cytokine field in particular. He has been unfailingly generous in sharing reagents and knowledge. Among his several positions, he served with distinction as President of the International Cytokine Society, has served on the scientific advisory board of the International Congress on TNF-related cytokines for many years, and chaired the International Cytokine Society Annual Meeting in 2001 in Maui soon after 9/11 in which Dr. Ware’s calm fortitude and concern were remarkable and contributed to the success of the meeting. He has also served on numerous boards and study sections including the editorial board of the Journal of Interferon and Cytokine Research from 1996 to the present. In addition to his many scientific accomplishments and service to the cytokine field, Dr. Ware has an outstanding record of mentorship with numerous successful trainees who have continued to shape the cytokine field all over the world.

Each year an ICIS member may be awarded Honorary Life Membership as a tribute to his/her contributions to the field. Nominees should be individuals who have made substantive contributions to the cytokine/chemokine/ interferon field over much of their careers, either in basic, clinical or applied research. Honorary members are esteemed members of the Society and provide us with a historical perspective and valued research tradition.

Award: ICIS Crystal. The Honorary Life Member is exempted from Society dues for his/her lifetime and is accorded all rights and privileges of an active member. Travel costs (flights and hotel) are reimbursed up to $1500 to attend the annual Meeting. Meeting registration is waived for the year of the award. Awardee to have the option to give a brief (~5min) acceptance speech at the Awards Ceremony.

Nomination process:

  • Letters of nomination are sent to the ICIS President via the ICIS website online nomination form. The nomination package includes a full CV of the nominee. The letter of nomination should detail the accomplishments of the nominee and reasons for the nomination. It should be noted that the awardees will be judged based on the following criteria which should be included in the nomination letter:
      • outstanding publications in the field and ground-breaking discoveries in the field
      • collective contributions to the cytokine/chemokine/ interferon field over much of their careers, either in basic, clinical or applied research.
  • A candidate may be nominated by more than one ICIS member.

Honorary Lifetime Membership has been awarded to the following individuals who have made substantive contributions to the cytokine/chemokine/interferon field over much of their careers, either in basic, clinical or applied research. Honorary members are esteemed members of the Society and provide us with an historical perspective and valued research tradition.

ICIS 2020 Honorary Lifetime Membership Award bestowed on Anne O’Garra

Anne O’Garra receiving the 2020 ICIS Honorary Lifetime Membership Award crystal at Cytokines 2020 Virtual Meeting.

Anne O’Garra is honored with the ICIS 2020 Honorary Lifetime Membership Awards as a tribute to her seminal and original contributions to our understanding of the role of cytokines in immunobiology and active engagement in cytokine research.

Anne O’Garra obtained her PhD in microbiology and undertook a Postdoctoral Fellowship in immunology at the Medical Research Council National Institute for Medical Research (NIMR; now part of the Francis Crick Institute) in London. At the DNAX Research Institute, California, USA (1987-2001), as an independent group leader, she defined functions and mechanisms for cytokines in the immune response, for which she was named 2nd of Highly Cited Authors in Immunology, 1992-2002 (ISI Science Indicators).

Anne O’Garra, FRS, FMedSci Senior Group Leader, Laboratory of Immunoregulation & Infection The Francis Crick Institute, London, England

Anne returned to the UK in 2001 to form the Division of Immunoregulation at NIMR, to interface research in immunology and infectious diseases. Anne continues research on the role and function of cytokines in the immune response and how key cytokines are regulated at the transcriptional level. Her group now also study the immune response in tuberculosis in mouse models and human disease. Anne stepped down from her position as Associate Research Director at the Francis Crick Institute in June 2019, remaining as Senior Group Leader to focus on her lab’s research on cytokines and the immune response in tuberculosis.

In addition to being a Fellow of the Royal Society, Anne was also elected a Fellow of the Academy of Medical Sciences, a Fellow of the American Association for the Advancement of Science and as a Member of EMBO, the European Molecular Biology Organization and is member of a number of Scientific Advisory Boards, including the Keystone Conferences and an Editor of the Journal of Experimental Medicine. As an advocate of Women-In-Science O’Garra chaired the Athena Swan Institute Pilot Bronze award for the NIMR.

She was co-chair of Cytokines 2018, 6th Annual Meeting of the International Cytokine & Interferon Society in Boston, Scientific Advisory Board and invited lecturer at Cytokines 2019 and is an ICIS Council Member.

*Anne O’Garra is also Professor of Infection Immunology, NHLI, Faculty of Medicine, Imperial College, London

Kouji Matsushima awarded the 2019 Honorary Lifetime Membership Award at Cytokines 2019 in Vienna
William Fleischmann awarded the 2018 Honorary Lifetime Membership Award at Cytokines 2018 in Boston
Ganes Sen awarded the 2017 Honorary Lifetime Membership Award at Cytokines 2017 in Kanazawa
Howard Young awarded the 2016 Honorary Lifetime Membership Award at Cytokines 2016 in San Francisco

Samuel Baron, Galveston, US (deceased)

Gerhard Bodo, Vienna, AT (deceased)

Derek Burke, Norwich-Norfolk, GB (deceased)

Kari Cantell, Helsinki, FI

Anthony Cerami, Tarrytown, US

Charles Chany, Paris, FR (deceased)

Alain de Weck, Bern, Switzerland (deceased)

Ferdinando Dianzani, Rome, IT (deceased)

Charles Dinarello, Aurora, US

Lois Epstein, Tiburon, US

Karl Fantes, Surrey  England, GB

Marc Feldmann, London, GB

Walter Fiers, Ghent, BE (deceased)

Norman Finter, Ludlow-Shropshire, GB (deceased)

Eleanor Fish, Toronto, CA

William Robert Fleischmann, Austin, US

Robert Friedman, Bethesda, US

George Galasso, Silver Spring, US

Laurie Glimcher, Boston, US

David Goeddel, San Francisco, US

Ion Gresser, Paris, FR (deceased)

Sidney Grossberg, Milwaukee, US

Otto Haller, Freiburg, DE

Gertrude Henle, Newton Square, US (deceased)

Ara Hovanessian, Paris, FR

Wolfgang Joklik, Durham, US (deceased)

Yoshimi Kawade, Sakyo-ku Kyoto, JP

Ian Kerr, London, GB

Tadamitsu Kishimoto, Osaka, JP

Ernest Knight, Jr., Kittery, US (deceased)

Peter Lengyel, New Haven, US

Warren Leonard, Bethesda, US

Jean Lindenmann, Zurich, CH (deceased)

Philip Marcus, Storrs, US (deceased)

Kouji Matsushima, Tokyo, JP

Thomas Merigan, Portola Valley, US

Donald Metcalf, Parkville, AU (deceased)

Yasuiti Nagano, Okayama 700, JP (deceased)

Anne O’Garra, London, US

Joost Oppenheim, Frederick, US

Keiko Ozato, Bethesda, US

William E. Paul, Bethesda, US (deceased)

Sidney Pestka, Piscataway, US (deceased)

Paula Pitha-Rowe, Baltimore, US (deceased)

Amanda Proudfoot, Geneva, CH (deceased)

Michel Revel, Rehovot, IL

Nancy Ruddle, New Haven, US

Leo Sachs, Rehovot, IL (deceased)

Charles Samuel, Santa Barbara, US

Ganes Sen, Cleveland, US

George Stark, Cleveland, US

Tadatsugu Taniguchi, Tokyo, JP

Michael Tovey, Villejuif, FR

Giorgio Trinchieri, Frederick, US

David Tyrrell, Whiteparish, GB (deceased)

Jan Vilcek, New York, US

Byron Waksman, Lexington, US (deceased)

Thomas Waldmann, Bethesda, US

Carl F. Ware, La Jolla, US

Charles Weissmann, Jupiter, US

Frederick Wheelock, Philadelphia, US

Howard Young, Frederick, US

Julius Youngner, Pittsburgh, US (deceased)

Kathryn Zoon, Bethesda, US