Understanding and Modulating Cytokine Activity through Structural Knowledge – ICIS Guest Symposium at AAI 2023

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Understanding and Modulating Cytokine Activity through Structural Knowledge – ICIS Guest Symposium at AAI 2023

Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time; Room 102AB

Chairs:

  • Juan L. Mendoza, University of Chicago, USA
  • Ignacio Moraga, University of Dundee, United Kingdom

Speakers:

  • Matthew C. Franklin, Regeneron, Structural insights into the assembly of gp130 family cytokine signaling complexes
  • Juan L. Mendoza, University of Chicago, The native JAK-JAK geometry in the type III IFN signaling complex limits the functional potency
  • Dylan Daniel, CytomX Therapeutics, Designing conditionally activated probody cytokines to localize antitumor activity to cancers
  • Ignacio Moraga, University of Dundee, United Kingdom, Manipulating cytokine activities in different extracellular microenvironments
  • Jamie B. Spangler, Johns Hopkins University, Dissecting immune biology using de novo engineered cytokines