Samuel P. Nobs, PhD
EMBO & SNSF Senior Postdoctoral Fellow, Laboratory of Prof. Elinav,
Department of Systems Immunology,
Weizmann Institute of Science,
Rehovot, Israel
Twitter: @NobsSamuel
Samuel P. Nobs is currently an EMBO and SNSF Postdoctoral Fellow in Prof. Eran Elinav’s laboratory at the Department of Systems Immunology at the Weizmann Institute of Science. His postdoctoral research focuses on how metabolism and the microbiome control inflammatory disease and infection in the lung. In his work he recently uncovered a novel molecular mechanism about why diabetes is associated with strongly heightened susceptibility to respiratory viral infection. In this work he could show that hyperglycemia drives a dysfunctional metabolic-epigenetic loop in lung dendritic cells that is preventing induction of protective antiviral immunity, viral clearance and survival.
Samuel received his Ph.D. from ETH Zurich under the supervision of Prof. Manfred Kopf. Samuel’s PhD research explored how tissue-specific factors control lung immunity. He discovered a critical role for PI3Kg in mediating lung dendritic cell development by controlling signaling downstream of the common growth factor receptor Flt3 exclusively in lung dendritic cells. Furthermore, he identified distinct and essential roles for PPARg and GM-CSF in driving allergic lung inflammation as key regulators of type 2 immunity, recruitment of granulocytes and chronic airway remodeling. Samuel completed his Master degree as an Excellence and Opportunity Scholar also at ETH Zurich in the same group where he studied the development and function of alveolar macrophages. He performed his undergraduate studies at Victoria University of Wellington with Graham Le Gros working on basic mechanisms of type 2 immunity.
Oral Presentation at Cytokines 2024 in Seoul, Korea:
“Lung Dendritic Cell Metabolism Underlies Susceptibility to Viral Infection in Diabetes”
