University of Minnesota
St Paul, Minnesota, United States
Lucy Sjaastad is a 4th year graduate student in Dr. Michael Farrar’s lab at the University of Minnesota. There she studies regulatory T-cell (Treg) development and functions during infection. Recently, Lucy and her collaborators identified a unique population of Tregs that express a strong interferon-stimulated gene (ISG) signature. These Tregs are present in mice at steady state and expand in the lungs and draining lymph nodes during infection with influenza A virus. Interestingly, ISG-Tregs emerge earlier during infection and express a distinct T-cell receptor repertoire by comparison to other lung infiltrating Tregs. The function of these cells is unknown. Using a novel mouse model that enables inducible depletion of ISG-Tregs, Lucy and her colleagues aim to dissect the function of these Tregs during influenza infection.
BEST iPoster Presentation at Cytokines 2021 Hybrid Meeting: ISG-Tregs in Viral Infection