2016 Inaugeral ICIS BioLegend William E. Paul Award

Dr. Locksley is the Director of the Sandler Asthma Basic ResearchCenter (SABRE) and a Howard Hughes Medical InstituteInvestigator. He is a Professor in the Departments of Medicine andMicrobiology & Immunology. He received his undergraduate degreein biochemistry from Harvard and his M.D. from the University ofRochester. After completing his residency at UCSF, he trained ininfectious diseases at the University of Washington. Prior to hisposition as director of the SABRE Center, Dr. Locksley served 18years as the Chief of the Division of Infectious Diseases at UCSFMedical Center. Dr. Locksley is a fellow of the American Academy ofArts and Sciences.Dr. Locksley’s laboratory focuses on mechanisms by which theimmune system becomes organized in stereotyped ways againstdiscrete types of challenges. This involves the differentiation ofnaïve helper T cells to subsets that produce different kinds ofcytokines, key effector molecules of the immune system. In turn,these different T cells subsets work with different kinds of innatecells, including neutrophils, eosinophils, macrophages and others,to mediate immunity. Properly executed, such responses mediateprotection against infectious organisms or repair of damagedtissues, but, when dysregulated, these immune responses lead todisease, including asthma.Dr. Locksley’s laboratory investigates immunity using micegenetically engineered to report cytokines expressed during allergicimmune responses. This approach reveals the shared expression ofimportant cytokines by innate and adaptive immune cells. Usingthese methods, the laboratory participated in the discovery of Group2 innate lymphoid cells, or ILC2s, which represent a previouslyunknown cell now implicated in allergic immunity. The ability tostudy the activation and organization of innate ILC2s uncovered arole for cells associated with allergy and asthma, such aseosinophils, in processes involved with basal metabolism and tissuehomeostasis. Activation of ILC2s in the small intestine wasimplicated in alteration of the mucosa to a secretory phenotypecharacterized by high numbers of goblet cells and tuft cells. Thelatter, a previously mysterious epithelial cell of unknown function,was shown to be the source of IL-25, a cytokine capable ofactivating ILC2s and other immune cells associated with allergy andasthma, thus opening up entirely new avenues for discovery.

Richard M. Locksley, MD

Session Chairs Weiping Jiang (L) and John O’Shea (R), awarding the 1st ICIS-BioLegend William E. Paul Award to Richard Locksley (C)

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