Amanda Jane Lynne Ridley Mainwaring, PhD
The Lydia Becker Institute of Immunology and Inflammation,
The University of Manchester
Manchester, UK
Dr Ridley undertook her PhD research investigating the expression and function of the chemokines CCL17 and CCL22 along with their receptor CCR4 during pulmonary type 2 inflammation. Supervised by Prof. Andrew MacDonald, Dr Peter Cook and Dr Maria Feeney.
Dr Ridley is now a postdoc in the lab of Dr Douglas Dyer where she is focusing on defining how chemokines and glycosaminoglycan (GAG) sugars on endothelial proteoglycans work together to facilitate leukocyte recruitment. During her time so far, she has demonstrated that chemokine localisation and availability is regulated by chemokines and their differential interactions with GAGs. Further, she was part of the team that identified that the chemokine CXCL4 drives widespread immune cell recruitment by interacting with extracellular matrix proteoglycans.
Dr Ridley has also secured funding to the sum of £20,000 to support her next steps of writing independent fellowship applications to pursue her career as a chemokine biologist.
Oral Presentation at Cytokines 2024 in Seoul, Korea:
“Myeloid derived CXCL4 is required for optimal neutrophil recruitment into the lung during pulmonary allergic inflammation “
