Associate Director, External Collaborations, Moderna Genomics

Website Moderna

The Role:

As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. We are building an independent research and business unit for genomic medicines, called Moderna Genomics (mGx) based in Technology Square, Cambridge, MA.  mGx will be an innovation engine for the company focused on discovering and delivering the next generation of in vivo gene editing and non-viral gene therapies.  It is our intention to be an industry leader in genomic medicines.

Moderna Genomics has an exciting opportunity for a discovery research leader to discover, innovate and optimize novel gene editing systems at Moderna Genomics (mGx) with our external collaborator. The Associate Director/Director works as a critical member of the mGx Team to establish Moderna as a leader in in-vivo gene editing therapeutics. She/he/they will work with the head of the group to build and develop a world-class team of scientists leading the research collaboration with mGx’s external partner. The candidate will have a strong background in DNA replication and repair, genetic mobile element biology and/or CRISPR systems. In addition, a proven record of “think-outside-the-box” conception and leadership of innovative programs in an industrial environment is required. The leader will drive research programs through critical go/no-go decisions and directly manage and develop a discovery research team. The Associate Director/Director will be a leader in shaping the gene editing strategy both internally and through key external alliances. This is an exciting and fast-paced position that will lead to new patents, journal publications, and scientific presentations to internal and external groups. Most importantly these new technology developments will used to create the next generation in vivo RNA based genomic medicines.


Here’s What You’ll Do:

Work with the Head of Novel Gene Editing System Discovery to build, lead and develop a team to discover and develop one or more novel gene editing technologies with our external collaborator
Propose, compare, and contribute to investment decisions amongst innovative approaches to develop CRISPR and non-CRISPR-based tools based on the needs of the company and in vivo gene editing field
Design, implement, and functionally characterize CRISPR and/or non-CRISPR-based tools for mammalian genome editing
Identify new technologies and collaborate with our external partner to advance Moderna Genomics’ in vivo gene editing system
Communicate results clearly and concisely, internally and externally
Keep accurate records of experiments and results
Here’s What You’ll Bring to the Table:

PhD in genetics, cell biology, biochemistry, molecular biology, or a closely related field
Extensive experience in academic, pharmaceutical or biotechnology company focused on gene editing tool development
Demonstrated proficiency in people management including building, leading, and developing direct reports
Demonstrated ability to manage external partners and alliances
Proven track record of design and development of novel CRISPR and non-CRISPR genome-editing systems and method development and/or genetic mobile elements
Extensive experience in molecular biology, mammalian cell biology techniques and assays
Strong background in medium to high throughput cell-based genome editing assays and building NGS libraries
Conversant in computational data analysis of genomic data to evaluate gene editing event outcomes
Excellent interpersonal, verbal, and written communication skills
Strong desire to work on early-stage technology development, implementing creative thinking to build Moderna Genomics’ genome-editing toolkit and patent portfolio
Additional positives:

Experience with Design of Experiment (DOE) methodologies
Experience performing protein mutagenesis and directed evolution
Experience with multiple modes of vector delivery (e.g., Lipid nanoparticle, viral vectors, nucleofection, etc.)
Familiarity with molecular visualization software (e.g., Pymol, CCP4, Chimera, etc.)

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