Conor Gruber, Ph.D.
Icahn School of Medicine at Mt. Sinai
New York City, USA
Conor is an MD/Ph.D. candidate in the laboratory of Dr. Dusan Bogunovic in the Center for Inborn Errors of Immunity at the Mount Sinai School of Medicine in New York, USA. Before joining Mount Sinai, Conor completed his undergraduate degree in Biology from Cornell University. He then worked in bioengineering, conducting research into the extra-tumoral cells and vesicles released from pancreatic cancers.
Now, his thesis research has focused on ultra-rare inborn errors of human JAK-STAT signaling. Specifically, Conor has investigated monogenic autoinflammatory disorders that hyperactivate JAK activity, including novel genetic mutations in JAK1 (Immunity 2020), STAT2 (JEM 2020), and ISG15 (Cell Reports 2020). During the COVID-19 pandemic, his research shifted toward studying the Multi-System Inflammatory Syndrome in Children, MIS-C (Cell 2020), a pediatric inflammatory disorder incited by the immune response to SARS-CoV-2. Conor’s work has been recognized by awards and grants from the Mindich Child Health and Development Institute, the National Institute of Health, and the European Society for Immunodeficiencies.
Now, he continues to research diseases of JAK-STAT biology, investigating human mutations in SOCS1, a universal regulator of JAKs. Conor will soon conclude his MD/Ph.D. studies and begin a Research Residency in Pediatrics at the Kravis Children’s Hospital at Mount Sinai. There, he will continue as a pediatric physician scientist studying genetic immune disorders.