Curt M. Horvath, PhD
Professor of Molecular Biosciences
Biochemistry, Molecular Biology and Cell Biology
Department of Molecular Biosciences
Curt M. Horvath is a Professor of Molecular Biosciences at Northwestern University with appointments in the Departments of Molecular Biosciences, Microbiology and Immunology, and Medicine, and serves as a basic science leader for Robert H. Lurie Comprehensive Cancer Center. He is the Director of the Northwestern Center for Cell, Developmental, and Systems Biology and the Northwestern High Throughput Analysis Laboratory. With over 25 years devoted to cytokine signal transduction, virology, innate immunity, and gene regulation, his research interests include cytokine-JAK-STAT and RLR-interferon signal transduction and mechanisms of cytokine-inducible gene regulation in the human immune response and in cancer biology. Among the first to recognize viral immune evasion strategies and characterize the molecular mechanisms underlying the degradation of STAT proteins and antagonism of RLR-MAVS-IFN pathways, his lab has used genomic techniques to study virus and IFN-stimulated gene regulation, reveal fundamental features of RNA polymerase regulation in innate immunity, and identify virus-induced small RNAs. Professor Horvath obtained his PhD from Northwestern University in 1992. He has won numerous awards and honors, including the Research Scholar Award from the American Cancer Society and was awarded the Jean Ruggles Rosomer Chair of Cancer Research, and was a Program leader in the NIAID Immune Mechanisms of Virus Control program from 2009-2014. He has served as consultant to projects including the RCSA, CBC, NIH, Merck, and Ligand pharmaceuticals.
Dr. Horvath is an active and highly committed members of the International Cytokine and Interferon Society (ICIS and its predecessors, the ISICR and ICS), serving multiple leadership roles, most recently elected to a second term on the ICIS Executive Council. In this capacity, he has spearheaded new programs for promoting diversity and inclusion among the ICIS leadership in the form of new trainee council positions. He was recognized in 2022 with an ICIS Distinguished Service Award. He is known for mentoring interactions with diverse groups of junior faculty, postdocs, and graduate students, and is a regular and enthusiastic participant in spontaneous jam sessions.