Sr. Scientist, Biomarkers and Assays

Website Moderna

The Power of mRNA

The Role:

Moderna Infectious Diseases is seeking a motivated Sr. Scientist with experience in supporting outsourced serological assays, cell-based assays and functional assays at CROs. The candidate will be part of teams responsible for advancing therapeutic and vaccine candidates from early discovery to clinical studies. The candidate will design and execute assays to evaluate novel vaccines and antibody-based therapies for viral and bacterial diseases. The work will include development of assays to evaluate immune responses to vaccination and to support the identification and selection of novel vaccine antigens as well as establishing immune correlate of protection. In addition, the candidate will help to identify, develop, and use novel immunological tools to identify vaccine approaches that work best for targets of interest. Located in Cambridge, MA, the candidate will support collaborations with external partners advancing into early clinical studies.

Here’s What You’ll Do:

Develop immunological assays to support Moderna vaccine development pipeline using diverse assay platforms such as MSD, Luminex, and Octet
Develop and support the routine performance of a variety of ligand binding assays, cell-based assays, neutralization assays as well as flow cytometry panels
Work closely with CROs to develop assays and immunological endpoint evaluations for supporting CMC product and process development.
Lead technical transfer of immunological assays to CROs and support life-cycle management of these outsourced assays
Work closely with cross-functional teams across the Moderna ecosystem, collaborators and CROs to progress candidates from Discovery through IND-enabling studies
Develop and implement a variety of functional assays to support the biological characterization of clinical and preclinical vaccine candidates
Support the evaluation of novel vaccine and therapeutic candidates in vitro and in vivo and ex vivo
Assist in the identification and validation of new targets for vaccine intervention
Identify and implement relevant novel immunological approaches and technology to accelerate infectious disease research
Manage multiple experiments, projects, and interactions with supporting functions simultaneously
Interpret, troubleshoot, and report complex data
Propose novel vaccine and therapeutic targets aligned with Moderna ID strategy
Here’s What You’ll Bring to the Table:

Ph.D. in Biology, Microbiology, Immunology, or Chemistry with at least 3 years of related postdoctoral research experience. Exceptional recent Ph.D. candidates would also be considered (title commensurate with experience)
Knowledge and experience in CMC process development for vaccines and therapeutics.
Experience in CRO management and academic collaborations
Deep understanding of Infectious disease pathogenesis and immunology
Expertise in the design and set up of a variety of serological assays, cell-based assays, and functional assays.
Demonstrated ability to design and execute new experimental approaches
Excellent team spirit, communication, and presentation skills
Contributions to high impact publications and presentations in the field of bacterial immunology and/or vaccinology.
Candidate will be curious in exploring new path for evaluating vaccine mediated responses, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes
Preferred: Expertise in supporting preclinical and clinical vaccine candidates.
Preferred: 3 years of independent research experience in the pharmaceutical or biotech industry

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