Scientist, T Cell Immunology, Infectious Disease Research

Website Moderna

Scientist, T Cell Immunology, Infectious Disease

Cambridge, MA


The Role:

The Infectious Diseases group at Moderna is seeking a talented and motivated Scientist with experience in Immunology with a particular focus on T cell responses in the context of respiratory viruses. The candidate will be part of teams responsible for advancing therapeutic and vaccine candidates in early discovery, through IND-enabling studies, and clinical trials. The candidate will design and execute experiments to evaluate novel T cell-based vaccines.  This work will include identifying vaccine targets and the development and execution of studies to evaluate T cell responses, including immune cell characterization, cytokine expression, and immunogenicity screening.  In addition, the candidate will help to identify, develop, and use novel immune screens to identify vaccine approaches that work best for targets of interest. The candidate will interface with collaborators and present results both internally and externally. The ability to effectively communicate across internal multi-disciplinary teams and with external partners is required. Applicants should be outstanding scientists, collaborative team members, excellent communicators, and should be excited to work with cutting edge mRNA technology in the advancement of vaccines against unmet infectious disease threats


Here’s What You’ll Do:

Assist in the identification of new T cell targets for vaccine intervention and / or identification of novel approaches that utilize the mRNA platform in the development of new or better respiratory virus vaccines
Conduct immunogenicity studies to characterize the interaction between immune system and formulated mRNA, including interpretation and presentation of results
Develop and implement new T cell focused assays
Develop relations with pre-clinical CROs and review pre-clinical immunology results
Run standard immunogenicity screens including intracellular cytokine staining and ELISpot
Review literature for relevant immune screening approaches and for new technology with application to infectious disease research
Manage multiple experiments, projects, and interactions with supporting functions simultaneously
Here’s What You’ll Bring to the Table:

Ph.D. in immunology or related field, or MSc with more than 5 years’ experience spent overseeing the interaction of the immune system with respiratory viruses or a related vaccine field, both with a T cell focus
Publication of original scientific work in high-quality journals
Demonstrated ability to design and execute new experimental approaches
Excellent team spirit, communication and presentation skills

Contributions to high impact publications and presentations in the field of immunology or vaccinology.
The ability to work in a cross-functional work environment is critical; strong leadership skills and independence skills are expected.
Excellent written, presentation and interpersonal communication skills; ability to influence and collaborate in a team environment.
Candidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes.
Preferred Qualifications:

Strong level of understanding and expertise in design and executing immune-related studies and assays with a T cell focus
Familiarity with cell metabolic pathway assessment a plus

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