Scientist, Immuno-Oncology

Website Moderna

Scientist, Immuno-Oncology

Cambridge, MA

Job Description

The Role:

Moderna is looking for a talented and motivated scientist to focus on discovery, design and preclinical development of new mRNA-based immunotherapies for cancer.  Successful candidates will contribute to advancing novel immune mediated therapies for cancer including enhancing immunostimulatory and inhibiting immunosuppressive pathways. Applicants should have a demonstrable track record of independent research accomplishments and be great team players. The ability to effectively communicate and collaborate with others, as well as a passion for drug discovery are required. Immuno-oncology or immunology experience is a plus.

Here’s What You’ll Do:

Design and demonstrate activity of novel mRNA targets with cellular and biochemical endpoints
Develop and validate in vitro/ ex vivo cellular models to test various mRNA therapeutics
Contribute to development of relevant in vivo models (syngeneic and xenografts models, humanized models with immune cells etc.)
Independently plan, organize samples and analyze experiments both ex vivo and in vivo with multiple endpoints
Deliver reproducible and impactful results under ambitious timelines. Analyze, interpret and present data with rigor
Rigorously document scientific work
Contribute to reports, regulatory submissions and presentations
Execute and troubleshoot standard protocols, adapt new protocols into practice with little assistance, and query literature to incorporate additional assays as needed
Here’s What You’ll Bring to the Table:

Ph.D. in immunology, oncology or other related biological sciences; or M.S. with extensive relevant experience
Solid background in immunology, immune-oncology and/or tumor biology research
Demonstrated ability to independently design and execute experimental plans for a preclinical drug development program
Expertise in multi-parameter flow cytometry, CyTOF/mass cytometry to phenotype murine, NHP and human immune populations
Experience in performing functional assays with primary immune cells such as T, NK, macrophage cells
Experience with biodistribution, pharmacokinetic, and pharmacodynamic analysis using biochemical and flow cytometry assays
Experience in nucleic acid and protein isolation and analysis techniques such as qPCR, ELISA/MSD, Luminex-based assays
Tissue/cell culture expertise:
o Cell passaging, archiving, transfection and cell-based functional assays

o Primary cell isolation and culture, particularly with hematopoietic cells

Scientific rigor, strong work ethic, good lab practices, results orientation, adaptable, strong communication skills

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