Sr. Scientist, Protein Engineering, Moderna Genomics

Website Moderna

The Role:

As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. We are building an independent research and business unit for genomic medicines, called Moderna Genomics (mGx) based in Technology Square, Cambridge, MA.  mGx will be an innovation engine for the company focused on discovering and delivering the next generation of in vivo gene editing and nonviral gene therapies.  It is our intention to be an industry leader in genomic medicines.


mGx seeks an experienced, curious and innovation-driven protein engineer to help power efforts to develop and optimize gene editing medicines.  The successful candidate will leverage his/her/their expertise to engineer novel proteins with improved activity and efficacy through rational design and/or directed evolution by designing and building high quality protein libraries, developing assays, and characterizing libraries using high-throughput screens and selections.  Demonstrated ability to think creatively and collaborate cross-functionally to drive innovative science is a must.  This role will have the opportunity to make an impact through establishing key protein engineering pipelines for mGx gene editing efforts and contributing to building the team and culture for this new initiative.


Here’s What You’ll Do:

Design and deploy workflows for rational protein engineering and directed evolution for the identification of improved gene editor variants
Build high quality protein libraries, and develop and execute assays for the characterization of those libraries through high-throughput screens and selections
Work with a team to assess function of evolved proteins in a variety of organisms and human cell types
Clearly communicate conclusions to the broader team and collaborate cross-functionally across the mGx team to drive projects across the portfolio from early discovery through lead optimization
Here’s What You’ll Bring to the Table:

A Ph.D. and postdoctoral experience in Molecular Biology, Biochemistry, Synthetic Biology, Bioengineering, or equivalent field
Significant expertise in synthetic biology, protein design, and/or directed evolution.
Experience with gene editing, computational protein design, microbial cloning, library generation, and multiple strategies to generate genetic diversity is preferred.
Ability to communicate complex scientific issues in a logical and coherent manner
Ability to work on multiple projects in a dynamic, fast-paced environment.
Ability to work independently and collaborate effectively in a cross-functional team

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