Postdoctor position

Website Eli Lilly & Company Eli Lilly & Company

Eli Lilly & Company

At Lilly, we unite caring with discovery to make life better for people around the world. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. Our San Diego site is growing in key areas. The Immunology research group focuses on discovering innovative biotherapeutic medicines treating autoimmune diseases and related complications. The position will be in Lilly San Diego Site.

We are seeking a Post-doctoral Research Scientist with a strong background in immunology and inflammatory diseases, preferably with experience studying immune cellular inhibitory receptor biology, signaling and cellular immunology. In addition to being suitable for publication, the work you pursue will involve understanding the mechanisms of action that drive the function and activities of therapeutic agonist antibody against inhibitory receptors in vitro and in vivo.

In this role you will have the opportunity to utilize these skills:

  • Human T cell biology including TCR signaling, co-receptor and inhibitory receptor signaling and cell proliferation
  • Characterize in vitro immune responses relevant to human autoimmune diseases. Perform flow cytometry characterization, analysis of gene expression and epigenetic change.
  • Single cell RNAseq and analysis of cellular transcriptomics.
    Generating gene-edited cells with CRISPR-Cas9 technology.
  • Investigating the mechanism of action for inhibitory receptor agonist antibodies.
  • Understanding the role of antibody Fc gamma receptors binding for agonism.
  • Actively collaborate with local external academic laboratories to source ideas, patient specimens, and technologies.
  • Record, analyze and communicate scientific ideas and data and also publish in peer-reviewed journal.

Basic Qualifications

  • Ph.D in Immunology/molecular cell biology or related scientific discipline
    Additional Skills/Preferences
  • Has deep expertise in working with primary human/rodent tissue/cells.
  • Knowledge and experience of in vivo pharmacology with various autoimmune/inflammatory disease models is a plus.
  • Cell-based assay development experience with special emphasis on functional genomic methods for target validation (e.g. shRNA, CRISPR-Cas9, flow cytometry).
  • Track record of scientific success proven by authorship on publications in excellent journals.

Additional Information

This position is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions at Lilly after your duration is complete.

About Eli Lilly’s Postdoctoral Scientist Program

Over the course of our company history, we have generated many innovative medicines on some of the toughest health care problems known to man – diabetes, heart disease, infectious diseases, neuroscience disorders, cancer, chronic immunologic diseases and more. We could not pursue this without our research and development team.

Postdoctoral scientists help us continue this pursuit. During your experience you will get:

·         Top industry research experience

·         Mentoring by some of Lilly’s top scientists

·         Laboratory and classroom training and education to further your development

·         Collaboration and networking across many other postdoctoral scientists and other researchers in both San Diego and Indianapolis sites

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

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