Website Quench Bio

Job Profile for Senior Scientist – Biology

Oct. 2018

QUENCH BIO is a seed-stage biotech company in stealth mode.  We are focused on developing novel, small molecule drugs in the auto-inflammation arena.  We have solid financial backing by both Atlas Venture and Arix Biosciences plc. and incubation space in the highly-collaborative Atlas Venture offices in Technology Square, Cambridge, MA.

We seek an experienced immunologist or cell biologist to join our team. This position offers the opportunity to join an immunology/inflammation-focused start-up from its inception, helping us to shape both the team and the drug discovery pipeline. With one program in-licensed from the Max Planck Institute and a goal of bringing 1-2 more into the company in the seed stage, we have a rich foundation on which to build an exciting company. The role requires a self-motivated scientist with superior communication and organizational skills who  can work collaboratively as part of a high-performing team, yet independently in the lab.

Job Requirements:

Design, develop and optimize cell-based assays of cytokine expression and release in engineered cell lines and primary human immune cells derived from peripheral blood
Design, develop and optimize cell-free, biochemical/biophysical assays of receptor binding and function
Contribute to the design and interpretation of rodent models of inflammation and autoimmunity
Document, analyze, interpret and present experimental data in a clear and concise manner
Proactively recognize and solve technical and scientific issues to ensure high quality data are generated for the progression of drug discovery projects
Read and interpret the latest scientific literature involving inflammasome research and techniques – actively summarize and communicate key new publications to larger team
Contribute to building a positive, team-oriented biotech culture
Education, Experience and Characteristics:

PhD in immunology or cellular & molecular biology with PhD or post-doc research experience in innate immunity/myeloid cell biology
Extensive hands-on experience with:
Cellular assay development including transient and stable transfection of inducible constructs for regulated gene expression
Plate-based endpoint assay instruments (e.g., multi-functional fluorescent plate readers, luminometers, Incucyte, high content platforms)
ELISA, HTRF, and/or cytometric bead-based (e.g., Lumiex) quantification of cytokines and/or secreted proteins
Isolation and purification of immune cells from human blood products (e.g. RosetteSEP purification of CD14+ monocytes from buffy coat preparations)
Flow cytometry staining, acquisition, and data analysis
Preparation of a wide variety of sample types and application of multiple downstream applications (e.g., protein isolation and Western blotting, RNA isolation for RNAseq and qRT-PCR, membrane preparations for biochemical assays of receptor function)
Demonstrated self-motivation and time management to efficiently conduct multiple laboratory and project tasks efficiently with little oversight
Ability to work in a team-oriented environment and demonstrate attention to detail and record keeping
Flexibility to rapidly adapt workplans to changing priorities and deadlines
Experience with in vivo inflammatory/autoimmune/metabolic or cardiovascular disease models is not necessary but is desired
Downstream statistical and bioinformatics analysis is not necessary but is desired
Interested candidates please contact:

Samantha S. Truex

Chief Executive Officer

Quench Bio | [email protected] | M: +1-508 561 6774

400 Technology Square, 10th Floor, Cambridge MA 02139

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